Yeast (Candida)

Yeast and bacteria make up the normal flora in the gastrointestinal tract.  Competition between the two species is what maintains the balance.   Antibiotics, poor diet, insufficient soluble fiber in the diet and poor gastric acid and digestive enzyme production can result in gastric dysbiosis in which yeast overgrowth occurs in the intestinal tract.  Probiotics and antifungal medications are commonly prescribed to fight dysbiosis but it can be a long and difficult battle. 

 Research has shown that prebiotics are more effective than probiotics in most cases to resolve dysbiosis.  Prebiotics are the optimal food for the bacterial flora in the intestines, whereas probiotics contain the favorable bacteria for the intestines.  The reason prebiotics have been more effective than probiotics at reversing dysbiosis is because it doesn’t do much good to just keep reintroducing the good bacteria into the intestinal tract if you don’t provide them with their optimal food source (soluble fiber).  Yeast is a very opportunistic organism, meaning they can thrive on a wide variety of food sources.  But the favorable bacterial flora in the intestines cannot.  The optimum food for the bacteria is soluble fiber,which our diets are becoming very deficient in.  Without this optimum food source of soluble fiber, the bacteria will not flourish, resulting in yeast overgrowth due to lack of competition from the bacteria.   Of course if the dysbiosis is due to the administration of antibiotics, then a probiotic would be indicated followed with prebiotics.

 A very good prebiotic is frucotooligosaccharides (FOS).  FOS is a soluble fiber consisting of sucrose and fructose but the way the two simple sugars are bound together, our body can’t digest them but the bacteria can flourish on them.  The exception to when FOS should not be supplemented is if a bad bacteria such as Klebsiella is present in the stool as this bad bacteria will flourish on FOS as well.  So the stools must be negative for the bad bacteria before supplementing FOS. 

 The key to supplementing FOS to get the most benefit is to take 2,000-3,000 mg of FOS all at one time each day.  The reason for this is as the bacteria utilize the FOS, they produce a protein the stimulates gene expression of two very important calcium binding proteins, Calbindin D9k and Calbindin D28k.  In order to stimulate gene expression, a particular protein must be present in a finite concentration, which is achieved if 2,000 –3,000 mg of FOS are taken all at once.  The Calbindin D9k is needed for calcium and other mineral absorption from the intestines.  The Calbindin D28k is needed to protect the cells from too much calcium influx that can result in cell damage and inflammation. 

 Many doctors and parents are reporting that the gastrointestinal problems including dysbiosis have resolved in their patients and children respectively after starting Respen-A with FOS.

Pro-biotic vs Pre-biotic for dysbiosis in the gut

Many parents have reported success in getting the calcium into their child by putting it in muffin mix, pancake or waffle mix.  Heating doesn’t appear to affect it. Many children continue on the probiotics with Respen-A and many have stopped the probiotics.  Research has shown that prebiotics such as FOS are more effective than probiotics in reversing dysbiosis in the gut.  The FOS is a soluble fiber made up of sucrose and fructose but the way they are bound, we can’t digest them but they are an excellent source of food for the bacteria in our gut.  If we feed the bacteria what they thrive on the best, the bacteria will multiply and through competition keep the yeast in check returning balance to the gut.  In fact science has calculated that if you were to feed one bacterial cell what it needed and removed its waste, within a 24 hour period, that one bacterial cell would multiply to create the mass of an aircraft carrier.  So you can see that when you feed the bacteria its optimal food such as FOS, there is no need to keep supplying bacteria such as in a probiotic.  The only time you don’t want to use FOS is if your stools are positive for Klebsiella which is a bad bacteria in the gut.  You would need to get rid of the Klebsiella before taking the FOS or else it will floursih as well on the FOS. 

 One important thing about taking FOS, don’t divide up the dose as directed on the bottle to get the optimal effect of FOS.  As the bacteria eat the FOS, they produce a protein that stimulates our bodies’ gene expression of two very important calcium binding proteins, calbindin D9k and calbindin D28k.  The calbindin D9k is needed for calcium and other mineral absorption from the intestines and calbindin D28k protects the cells from too much calcium influx into the cells that can cause exitotoxicity and result in inflammation and cell damage.  Whenever you are stimulating gene expression, the protein concentration must be within a finite range.  2,000 -3,000 mg of FOS must be taken all at once in order to get this protein produced by the bacteria in the finite range to stimulate the production of the calcium binding proteins.